We are living in a culture where anything goes. Because of man's fallen state as a result of sin there seems to be a lot of confusion. This confusion even extends to gender identity where some men believe they are female and vice versa. 

Those who believe and support this idea of gender-neutrality have simply rejected the design of creation by God Himself. 

To get a better understanding, we must take a look and understand how and in what manner God created human beings. In Genesis 1:27 the scripture declares 

27 So God created man in His own image; in the image of God He created him; male and female He created them.

This simply means that there are only two genders that are revealed by God and His word. Although society views gender identity based on individual beliefs, perceptions, and social construct, the Bible always associates gender with the two sexes...male and female. So the idea that there are multiple genders is an unbiblical concept that seeks to destroy how God designed us and His entire purpose for creating us in the first place. 

Many will argue that gender and sex are two separate things, and what a person wears is a product of social construct in the first place. However, the scripture tells us in Deuteronomy 22:5 that a woman is not to wear men's clothing and men are not to wear women's clothing because that is an abomination to God. 

The idea that clothing, high heels, and make-up are all just socially constructed today is preposterous seeing as the bible speaks this issue. This means that there has been a distinction between male and female clothing for thousands of years.

As Christians, we are required to confront the sinful issues of today with biblical truth. God made men and women different (Gen. 1:27). Contrary to mistaken interpretations, sexual difference does not exist on a continuum where some men are more like women or vice versa. Men and women are different at the deepest levels of their being. Our chromosomes are different. Our brains are different. Our voices are different. Our body shapes are different. Our body strengths are different. Our reproductive systems are different. Most everything about us is different.

Because men and women are different, it’s philosophically impossible for a man to become a physical woman or a physical woman to become a man, no matter what the culture may say. Those who say otherwise are trafficking in fiction about human nature. In fact, there is no scientific proof to verify the claim that one is trapped inside the wrong body.

If God made men and women fundamentally and comprehensively different, then the idea that a man could ever become a woman (or vice versa) is simply impossible. According to one author, the differences between men and women can’t be overcome simply because one person feels they’re a member of the opposite sex. Your psychology (feelings) cannot change your ontology (being).

This starts early in life with our children growing up in this confused world that are bombarded with messages of confusion. Little boys are told they don’t have to be boys; girls are told they might not really be girls. Whatever they feel they are is what they are—boy, girl, or a mixture of the two. The world tells them it doesn’t matter. The confusion and ambiguity are reinforced in many ways: gender-neutral days at school, the banning of terms such as boys and girls in the classroom, unisex restrooms, curricula that promotes homosexual marriage, and the list goes on. It’s little wonder that some people grow up struggling with their sexual identity.

As Christians, we should be concerned about those who are struggling with gender dysphoria. Whether or not we think there confusion is real, we should 
welcome all into the grace of the gospel, because our gospel is applicable and available to all (1 Tim. 2:4; who desires all people to be saved and to come to the knowledge of the truth.)

2 Pet. 3:9 The Lord is not slow to fulfill his promise as some count slowness, but is patient toward you, not wishing that any should perish, but that all should reach repentance.) So, first and foremost, we must offer genuine love to our gender dysphoric neighbor 

Mark 12:30–31
30 And you shall love the Lord your God with all your heart and with all your soul and with all your mind and with all your strength.’ 31 The second is this: ‘You shall love your neighbor as yourself.’ There is no other commandment greater than these.”

In understanding why people may be confused on the issue of gender, it is important that we not just parrot what the world says. As Christians, we must meet the world with truth, and at the same time offer hope and love through compassion. 

(Prov. 3:5–65 Trust in the LORD with all your heart,
and do not lean on your own understanding.
6 In all your ways acknowledge him,
and he will make straight your paths.)

Biblical counsel would begin by helping a person embrace, however difficult it may seem, that their birth sex is a testimony to their true nature, and that perceptions of a different gender identity, while sincere, do not constitute an actual identity change.

The Bible says that God created “male and female” and He pronounced His creation as "good" (Genesis 1:27, 31). God’s plan was perfect, but, as with everything in mankind’s sphere, perfection was corrupted by sin in the garden of Eden with Adam and Eve. 

Romans 5:12 Therefore, just as sin came into the world through one man, and death through sin, and so death spread to all men because all sinned—

Sin brought deviations from God's perfect creation and standard and we would be hard pressed to understand where sin's contamination ends in the creation. Could this contamination of sin affect people physically and mentally? The answer is yes. And the answer resides in salvation in Christ.

Truth is, we are involved in a spiritual battle for our souls. According to Pauls letter to the Romans in 12:1-2, we are being forced to conform to the world's mold. Instead, we are commanded to be transformed by the renewing of our minds. That means those with gender confusion must have their minds renewed and the only way that can be done is through personal relationship with Jesus Christ. 

Satan does everything he can to kill, steal, destroy and deceive us into questioning God's plan. One of the devil’s ploys is to make us dissatisfied with how God made us. 

We know that the whole world longs for the day when Jesus returns to make right all wrongs. The curse of sin will one day be lifted. This is possible because of the redemption that we have in Jesus Christ. Through salvation, Jesus Christ grants us forgiveness of sin and deals with all of our brokenness, even those struggling with gender identity issues. 

Many people battle with temptation, greed, pride, anger, or any number of sins. Someone else may battle gender confusion. Regardless of the battle with sin and the devil’s lies, the question we must answer is, “Is Christ and His redemptive work sufficient for our battles?” The answer to that question is a resounding YES! 

Jesus definitely claims to be sufficient for any and all of our battles, and He desires to sanctify us through His Word of truth (John 17:17).

As children of God, we should be content in this life (Philippians 4:11) Not that I am speaking of being in need, for I have learned in whatever situation I am to be content.)

2 Corinthians 12:10 Therefore I take pleasure in infirmities, in reproaches, in needs, in persecutions, in distresses, for Christ’s sake. For when I am weak, then I am strong.

We realize that we all have limitations, physically, mentally, emotionally, and spiritually. But when we yield to God's design and plan for us, those limitations can be overcome through His strength and power. 

If a person feels he or she has been born as the wrong gender, the answer is not gender-reassignment surgery, hormone therapy, cross-dressing, etc. This is simply giving in to the devil’s lies.

Listen, God does not make mistakes and any person who feels like they were born in the wrong body needs to come to the understanding that they are desperately in need of the to experience the transforming power of Christ. 

And as Christians, we should be willing to sit down with or walk alongside someone who is experiencing gender confusion and help them understand the Gospel and the transforming power of Christ.