Holmes & Watson is a comedic spin on the legendary detective Sherlock Holmes and his loyal companion, Dr. John Watson. In this farcical take, the duo (played by Will Ferrell and John C. Reilly) bumble their way through a case involving a plot to assassinate Queen Victoria. Despite their reputation as brilliant crime-solvers, the pair constantly find themselves in absurd situations that test their deductive reasoning (and patience).

The film features a mix of slapstick humor, outrageous gags, and pop-culture nods, as Holmes and Watson attempt to thwart the villainous Professor Moriarty. Along the way, they encounter a host of quirky characters, including unlikely romantic interests and skeptical Scotland Yard detectives. Their antics often cause chaos, but somehow they muddle through to uncover the truth.

Though it plays fast and loose with the source material, the film is meant to be a tongue-in-cheek parody rather than a faithful adaptation of Arthur Conan Doyle's classic stories.