Hosts Mitsuaki Sawano, MD, and Kentaro Ejiri, MD, highlight two JACC papers simultaneously published at ESC 2025. Prediction of Aortic Stenosis Progression Using Artificial Intelligence: A Machine Learning Model reports an interpretable algorithm using echo parameters alone to forecast AS progression within 5 years. Mechanistic Basis for Differential Effects of Interatrial Shunt Treatment in HFrEF vs HFpEF: The RELIEVE-HF Trial examines structural and hemodynamic differences explaining why shunt therapy reduced LV volumes in HFrEF but increased PASP and RA area in HFpEF.