Dennis Wigle and Linda Martin from Mayo Clinic and University of Virginia, respectively, discuss recent trials from the meeting of the European Society for Medical Oncology (ESMO), particularly highlighting the ALINA trial focusing on adjuvant treatments for resected non small cell lung cancers with impressive differences in outcomes between Alectinib and platinum-based chemotherapy. In addition, they provide a review of multiple perioperative immunotherapy trials from 2023 and share their hopes for the field in 2024. This podcast is sponsored by Genentech.