Esophageal cancer remains one of the most lethal malignancies of the digestive tract, responsible for approximately one in twenty cancer-related deaths globally. More than 500,000 new cases were diagnosed worldwide in 2022, with the burden especially high in East Asia and certain regions of Africa.

In the United States, the American Cancer Society (ACS)  reports over 22,000 new cases in 2025, and the overall five-year survival rate remains under 25%, reflecting the disease’s aggressive nature and typically late presentation. However, recent years have seen promising advances, with new treatment for esophageal cancer emerging through targeted therapies, immunotherapy, and precision-guided surgical techniques.

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