This podcast is a follow up to Bayer’s symposium at ESC 2021 ‘Evolving Cardiovascular Risk: Your Patient’s Past, Present and Future’.

Following on from the discussions at that meeting, Professor Craig Coleman and Professor Roxana Mehran provide further expert perspectives on the importance of considering your patient’s kidney function when they have atrial fibrillation, and discuss how to protect patients from the devastating effects of stroke.

Professor Manesh Patel and Dr Rónán Collins then focus on stroke prevention in older patients with atrial fibrillation and highlight the fascinating studies that caught their eye among the ESC scientific programme.

Further details:

• Read the 2020 ESC guidelines for the management of atrial fibrillation here: https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Atrial-Fibrillation-Management

• Find the 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation here: https://www.ahajournals.org/doi/10.1161/CIR.0000000000000665

• The EHRA practical guide on the use of NOACs in patients with atrial fibrillation can be accessed here: https://academic.oup.com/europace/article/23/10/1612/6247378

• Real-world evidence from the ANTENNA study showing the benefit of rivaroxaban versus warfarin for the treatment of renal decline in patients with atrial fibrillation is available here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=104597

• The study by Bonand et al. demonstrating the benefits of NOACs versus vitamin-K antagonists in patients older than 80 years with atrial fibrillation can be seen here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=107076

• Data from the EMIR study regarding treatment of elderly patients with atrial fibrillation with rivaroxaban can be seen here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=107122

• The study by Lee et al. confirming the positive net clinical benefits of NOACs in elderly patients with high bleeding risk and atrial fibrillation is available here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=104607

• Data presented by Chao et al. on the impact of off-label dosing of NOACs in elderly patients can be found here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=105312

• Data from the ETNA-AF study can be accessed here: https://esc2021-abstract.medicalcongress.online/mediatheque/media.aspx?channel=103467&mediaId=105275

• The original publication of the ARISTOTLE trial can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa1107039

• Access to the ROCKET AF original publication can be found here: https://www.nejm.org/doi/full/10.1056/nejmoa1009638

• The XANTUS primary publication can be found here: https://academic.oup.com/eurheartj/article/37/14/1145/2466063

• For anticoagulant dosing information, see the European labels for apixaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002148/WC500107728.pdf), dabigatran (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf), edoxaban (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002629/WC500189045.pdf), rivaroxaban (https://www.ema.europa.eu/documents/product-information/xarelto-epar-product-information_en.pdf) and warfarin (https://www.medicines.org.uk/emc/product/3064/smpc)

Show notes: MA-M_RIV-ALL-1126-1

Recording: MA-M_RIV-ALL-1125-1