Emily Greenstein, APRN, CNP, CWON-AP, FACCWS and Terry Treadwell, MD, FACS, FAAWC explain the critical importance of compression therapy as the cornerstone of VLU management, review best practices in compression therapy and skin and wound care to optimize VLU management, explore clinical decision-making prior to implementing compression to manage edema across the spectrum, evaluate the science and clinical application of 2-layer compression therapy, and investigate the use of compression wraps to manage edema associated with diabetic ulcers.