Recently, a method was described that combines the sensitivity of single-molecule counting with the convenience of dried spot collection.  The study evaluates three conventional protein analytes routinely measured in the clinical lab: Troponin I, Prostate Specific Antigen (PSA), and C-reaction protein.  The authors detailed the assay method that incorporates spot-scanning to account for dried blood spot variability followed by analysis with single-molecule counting.  “Expanding the Utility of High-Sensitivity Dried Blood Spot Immunoassay Testing with Single Molecule Counting” was published in the March 2018 issue of The Journal of Applied Laboratory Medicine.