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01:45 Case: Neonate with repeated umblical bleeding. IC haemorrhage.  Normal Factors (so far), Normal VW screen, Normal FBC and normal film.

05:35 Factor XIII (13): function and presentations in deficiency 

09:45 Testing, testing! 

• ELISA/Ammonia Release Assay then a Mutational Analysis 
• Honarable mention: Clot Solubility Assay

16:00 Fibrinolysis definition and pathway

21:00 Activators of Fibrinolysis: tPA vs. uPA 

23:23 Inhibitors of Fibrinolysis: PAI-1, PAI-2, TAFI, α2-antiplasmin, and Factor XIII (13)

26:28 Thrombolysis: defintion, examples and uses

32:20 Case: Thromboembolic stroke, thrombolysis 24 hours prior, haemorrhagic transformation

36:19: Tranexamic Acid (Hari’s favourite drug)

• Honarable mention: Dr Utako Okamoto and the WOMAN trial
• CRASH 2 and CRASH 3 trials
• HALT-IT trial

41:22 D-Dimer 

44:00 Summary

'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK.

Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning.

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