JACI: In Practice Editor-in-Chief Michael Schatz describes the February 2022 issue, the theme of which is “Difficult-to-Control Asthma.” Theme topics covered include difficult-to-control asthma management in children and adults; the impact of adherence, health literacy, and comorbidities on difficult-to-control asthma; and the use of biologics in patients with difficult-to-control asthma. Dr. Schatz then presents the Highlights of the Original Articles in the issue, which are on the topics of Severe Asthma, Anaphylaxis, Dermatitis, Drug Allergy, Food Allergy, Rhinitis, Urticaria, and Vocal Cord Dysfunction. Read the issue: https://bit.ly/JAIPFeb2022. Access JACI: In Practice’s entire library: https://www.jaci-inpractice.org.