JACI: In Practice Associate Editor David Khan describes the February 2023 issue, the theme of which is “Drug Allergy”. Theme topics covered include Practice Parameter updates; placebo, nocebo and patient reported outcome measures in drug allergy; perioperative hypersensitivity; and various aspects of penicillin allergy. Dr. Khan then presents the Highlights of the Original Articles in the issue, which are on the topics of Drug Allergy, Asthma, Food Allergy, Mast Cell Disorders, Rhinitis and Sinusitis, and Urticaria and Angioedema.