Researchers at Scripps Research have achieved the unprecedented—redesigning fentanyl at the molecular level to preserve pain relief while dramatically reducing fatal respiratory depression and addiction potential. Also covered: a patient who survived 48 hours without lungs using artificial life support, evidence that early Earth microbes were breathing oxygen hundreds of millions of years before the Great Oxidation Event, and a CRISPR tool that reverses antibiotic resistance in superbugs. Plus, a 125-million-year-old dinosaur with never-before-seen hollow spikes, breakthrough silicon photonics, and engineered stem cells that mass-produce cancer-fighting immune cells.

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