"You are losing control. You are losing something you had hoped for." That is how Dr. Vasiliki Moragianni describes what a pregnancy loss actually takes from you, and it is exactly why this conversation matters so much.
This week we sit down with Dr. Vasiliki Moragianni, double board certified reproductive endocrinologist and the founder and director of the Recurrent Pregnancy Loss Center at Johns Hopkins, for an honest and compassionate look at recurrent pregnancy loss (RPL). We get into what RPL actually is, why the definition just changed, what a thorough evaluation really looks like, and what hope looks like on the other side. Whether you are a patient, a partner, or someone caring for people walking through this, Dr. Moragianni brings both rigorous evidence based medicine and real warmth to a topic that far too many people carry in silence.
In this episode, we cover:
- The brand new definition of recurrent pregnancy loss and why two losses now open the door to a full evaluation
- How common RPL really is, and why so many cases come back "unexplained"
- The most common causes, from chromosomal factors to thyroid, uterine issues, and antiphospholipid syndrome
- The real evidence behind controversial tests and treatments like NK cell testing, intralipids, and IVIG
- Why recurrent pregnancy loss is almost never your fault, no matter how many times you have asked yourself that question
- When it is safe to try again after a loss
- The case for a multidisciplinary team, and why mental health support belongs at the very center of it
More than anything, this episode is a reminder that you are not alone, that pregnancy loss is far more common than anyone lets on, and that the data on hope is real. Having multiple losses behind you does not mean a healthy pregnancy is not still ahead of you.
If you have experienced loss, love someone who has, or simply want to understand this better, this episode is for you.
**A gentle note before you listen: this episode discusses pregnancy loss and grief. Take it in whatever size pieces feel right, pause and come back to it if you need to, and if anything heavier comes up, please reach out to a qualified mental health professional. If you are in crisis, you can call or text the 988 Suicide and Crisis Lifeline.
Connect with Dr. Vasiliki Moragianni:
Instagram: https://www.instagram.com/drmoragiannifertility
Website: https://www.hopkinsmedicine.org/gynecology-obstetrics/specialty-areas/fertility-center/recurrent-pregnancy-loss-center