Unravel the mystery of Fever of Unknown Origin (FUO) in this 88 Diagnoses episode, straight from the UpToDate article! Dive into its four categories—classic, healthcare-associated, immunocompromised, and travel-associated—with a focus on systematic evaluation and management. Learn through detailed history-taking, physical exams, initial tests, and advanced diagnostics like PET/CT. Enjoy 3 mnemonic-driven segments, 4-5 ward-ready tips, resident anecdotes, 3-4 ‘pause and think’ prompts, and a case study with a diagnostic twist. Each subtopic wraps with “if you can’t remember everything, remember this!” Listen now, apply a tip on rounds, and share feedback to conquer FUO!