This release contains only the music track from Base by Base Episode 21.

Song title: Filter the Noise, Find the Signal
Original Base by Base episode: 21: Pooled prime editing maps functional human variants at scale

Article metadata:
Article title: High-throughput screening of human genetic variants by pooled prime editing
Journal: Cell Genomics
DOI: 10.1016/j.xgen.2025.100814
Reference: Herger M., Kajba C.M., Buckley M., Cunha A., Strom M., Findlay G.M. (2025). High-throughput screening of human genetic variants by pooled prime editing. Cell Genomics 5, 100814. https://doi.org/10.1016/j.xgen.2025.100814

Lyrics:
Verse 1
We light up the bench with a borrowed spark,
Little paper guides in a library dark,
Thousands of letters, one cell at a time,
Trying to make the genome bend in rhyme.

Pre-Chorus
But some paths don’t cut, some edits don’t stay,
Some guides look loud in a misleading way,
So we build a mirror to tell what is real,
A surrogate sign that the cells can reveal.

Chorus
Filter the noise, find the signal in the flood,
Let the clean edits rise up in the blood,
Keep what works, let the dead ends go,
In the native code where the true things show.
Filter the noise, find the signal tonight,
From uncertain lines to a verdict of light.

Verse 2
We co-select survivors, tighten the screen,
Watch function scores paint the places between,
Some changes break splices, some silence a gene,
Some turn a warning into something seen.

Bridge
Not every guide can carry the weight,
Not every readout can settle the fate,
But when the proxy and the genome agree,
We map what matters, variant by variant, free.

Final Chorus
Filter the noise, find the signal in the flood,
Let the clean edits rise up in the blood,
Name the harmful, spare the unsure,
Give the next test something sharp and pure.
Filter the noise, find the signal tonight,
From a thousand maybes to a path that’s right.