Matthew 16:24-26 says that those who follow Jesus must deny themselves and take up their cross. This means humbling ourselves and prioritizing following God's will. This may be seen in examples of Jesus' humility, like when he humbled himself to become a servant and obey God's will. We should not expect our experience following Christ to be easy or comfortable, but should trust in God's provision and have faith in his promises. The podcast discusses the concept of "picking up our cross" as it relates to following Jesus. This means denying ourselves, humbling ourselves, and having faith in God. Each person's path may look different, but the ultimate goal is to have faith and trust in Jesus. The host encourages listeners to examine their hearts and be willing to lay down whatever God is calling them to in order to follow Him more closely.