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Forth CoVid Shot Is Protective
Vidcast: https://youtu.be/i0ImNC_9tn8
A 4th shot of either the Moderna or Pfizer CoVid vaccine bumps CoVid neutralizing antibodies and actual Omicron virus neutralization by a factor of 8 to 10 fold while preventing both infections and hospitalizations. These conclusions come from an Israeli study comparing the CoVid immunity and health status of 274 health care workers who received 4th shots representing a second booster of mRNA CoVid vaccines with 245 matched controls who received only 3 shots of the same vaccines. These booster shots were given roughly 5 months after each of the previous shots.
Looking first at the effect of the 4th shot on the recipients’ immune status, the 4th dose of either mRNA vaccine restores the IgG anti-CoVid antibody levels to those following the 3rd dose representing a 9-10 fold boost in antibody level from that prior to the 4th shot. In terms of live Omicron virus neutralization capability, the 4th shot of Pfizer bumped it 10.6 fold and the 4th shot of Moderna bumped it 18.8 fold
Looking at cellular immunity, the 4th dose of the Pfizer increased the proportion of responders a modest 10% from 50 to 60% with no significant increase in the numbers of activated T cells. On the other hand, the 4th dose of Moderna increased the proportion of responders from 61 to 87% and the numbers of activated T cells from 72 to 203.
Looking at vaccine efficiency for preventing any Omicron infection, the 4th shot of Pfizer reduced the incidence by 30% while that of Moderna reduced it by 11% for an average of 20.5%. Then looking at the vaccine efficiency for preventing more symptomatic CoVid infections, the 4th of Pfizer reduced the incidence by 43% while the 4th of Moderna reduced it by 31% for an average of 37%. Moderna’s 4th shot capabilities seemed lower than Pfizer’s but that is likely due to the fact that the first 3 shots of Moderna were overall more effective.
These stats seem unimpressive until you consider that these efficiencies are boosts over and above the protection seen for the 3 shots alone. Let’s review the graph I showed you last week for the 3rd shot effectiveness and add to it this data from a 4th shot. Adding that 4th shot brings the vaccine effectiveness preventing severe CoVid back up from 65% toward 100%.
The 4th doses of either vaccine did not lead to any significant adverse events but only the typical local ache at the vaccine site and mild systemic symptoms.
https://www.medrxiv.org/content/10.1101/2022.02.15.22270948v1.full.pdf
#CoVid #boosters #4thshot #antibodies #neutralization #vaccineeffectiveness
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By Howard G. Smith MD, AM
Vidcast: https://youtu.be/i0ImNC_9tn8
A 4th shot of either the Moderna or Pfizer CoVid vaccine bumps CoVid neutralizing antibodies and actual Omicron virus neutralization by a factor of 8 to 10 fold while preventing both infections and hospitalizations. These conclusions come from an Israeli study comparing the CoVid immunity and health status of 274 health care workers who received 4th shots representing a second booster of mRNA CoVid vaccines with 245 matched controls who received only 3 shots of the same vaccines. These booster shots were given roughly 5 months after each of the previous shots.
Looking first at the effect of the 4th shot on the recipients’ immune status, the 4th dose of either mRNA vaccine restores the IgG anti-CoVid antibody levels to those following the 3rd dose representing a 9-10 fold boost in antibody level from that prior to the 4th shot. In terms of live Omicron virus neutralization capability, the 4th shot of Pfizer bumped it 10.6 fold and the 4th shot of Moderna bumped it 18.8 fold
Looking at cellular immunity, the 4th dose of the Pfizer increased the proportion of responders a modest 10% from 50 to 60% with no significant increase in the numbers of activated T cells. On the other hand, the 4th dose of Moderna increased the proportion of responders from 61 to 87% and the numbers of activated T cells from 72 to 203.
Looking at vaccine efficiency for preventing any Omicron infection, the 4th shot of Pfizer reduced the incidence by 30% while that of Moderna reduced it by 11% for an average of 20.5%. Then looking at the vaccine efficiency for preventing more symptomatic CoVid infections, the 4th of Pfizer reduced the incidence by 43% while the 4th of Moderna reduced it by 31% for an average of 37%. Moderna’s 4th shot capabilities seemed lower than Pfizer’s but that is likely due to the fact that the first 3 shots of Moderna were overall more effective.
These stats seem unimpressive until you consider that these efficiencies are boosts over and above the protection seen for the 3 shots alone. Let’s review the graph I showed you last week for the 3rd shot effectiveness and add to it this data from a 4th shot. Adding that 4th shot brings the vaccine effectiveness preventing severe CoVid back up from 65% toward 100%.
The 4th doses of either vaccine did not lead to any significant adverse events but only the typical local ache at the vaccine site and mild systemic symptoms.
https://www.medrxiv.org/content/10.1101/2022.02.15.22270948v1.full.pdf
#CoVid #boosters #4thshot #antibodies #neutralization #vaccineeffectiveness