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From Insulin to Acidosis – Understanding Diabetic Emergencies
đź”— Check out all our links, sources, and socials:https://linktr.ee/thecadaverslessons
Diabetic emergencies remain among the most dangerous—and most misunderstood—conditions encountered in medicine. In this episode of The Cadaver's Lessons, we explore the science, history, and clinical management of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) while tracing the incredible evolution of diabetes care from the discovery of insulin to today's cutting-edge technology.
Learn how insulin transformed from crude animal extracts into genetically engineered human insulin, why electrolyte management can mean the difference between life and death, and how modern tools like continuous glucose monitors (CGMs), insulin pumps, and artificial pancreas systems are reshaping the future of diabetes treatment.
Whether you're a healthcare professional, student, or simply fascinated by medical history, this episode blends real clinical cases, pathophysiology, history, and ethics into one comprehensive discussion.
đź“š ReferencesÂ
- Kitabchi, A. E., Umpierrez, G. E., Miles, J. M., & Fisher, J. N. (2024). Adult diabetic ketoacidosis. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK560723/
- Pasquel, F. J., & Umpierrez, G. E. (2024). Hyperosmolar hyperglycemic state. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482142/
- Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2025). Type 1 diabetes. New England Journal of Medicine, 393(1), 34–48. https://pmc.ncbi.nlm.nih.gov/articles/PMC11745827/
- Reddy, P., & Jialal, I. (2024). Biochemistry, metabolic acidosis. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK551568/
- Heinemann, L., & Hompesch, M. (2018). Biosimilar insulins: Guidance for data interpretation by clinicians and users. Diabetes, Obesity and Metabolism, 20(11), 2543–2548. https://pmc.ncbi.nlm.nih.gov/articles/PMC6205949/
- American Diabetes Association. (2022, January 11). The history of the wonderful thing we call insulin. https://diabetes.org/blog/history-wonderful-thing-we-call-insulin
- Smithsonian Institution. (n.d.). Two tons of pig parts: Making insulin in the 1920s. National Museum of American History. https://americanhistory.si.edu/explore/stories/two-tons-pig-parts-making-insulin-1920s
- American Chemical Society. (n.d.). Insulin. National Historic Chemical Landmarks.
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By Bernadette & Samantha Smithđź”— Check out all our links, sources, and socials:https://linktr.ee/thecadaverslessons
Diabetic emergencies remain among the most dangerous—and most misunderstood—conditions encountered in medicine. In this episode of The Cadaver's Lessons, we explore the science, history, and clinical management of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) while tracing the incredible evolution of diabetes care from the discovery of insulin to today's cutting-edge technology.
Learn how insulin transformed from crude animal extracts into genetically engineered human insulin, why electrolyte management can mean the difference between life and death, and how modern tools like continuous glucose monitors (CGMs), insulin pumps, and artificial pancreas systems are reshaping the future of diabetes treatment.
Whether you're a healthcare professional, student, or simply fascinated by medical history, this episode blends real clinical cases, pathophysiology, history, and ethics into one comprehensive discussion.
đź“š ReferencesÂ
- Kitabchi, A. E., Umpierrez, G. E., Miles, J. M., & Fisher, J. N. (2024). Adult diabetic ketoacidosis. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK560723/
- Pasquel, F. J., & Umpierrez, G. E. (2024). Hyperosmolar hyperglycemic state. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482142/
- Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2025). Type 1 diabetes. New England Journal of Medicine, 393(1), 34–48. https://pmc.ncbi.nlm.nih.gov/articles/PMC11745827/
- Reddy, P., & Jialal, I. (2024). Biochemistry, metabolic acidosis. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK551568/
- Heinemann, L., & Hompesch, M. (2018). Biosimilar insulins: Guidance for data interpretation by clinicians and users. Diabetes, Obesity and Metabolism, 20(11), 2543–2548. https://pmc.ncbi.nlm.nih.gov/articles/PMC6205949/
- American Diabetes Association. (2022, January 11). The history of the wonderful thing we call insulin. https://diabetes.org/blog/history-wonderful-thing-we-call-insulin
- Smithsonian Institution. (n.d.). Two tons of pig parts: Making insulin in the 1920s. National Museum of American History. https://americanhistory.si.edu/explore/stories/two-tons-pig-parts-making-insulin-1920s
- American Chemical Society. (n.d.). Insulin. National Historic Chemical Landmarks.