The 2025 OWASP Top 10 reveals a fundamental shift in application security, showing how threats have transformed from simple code flaws like buffer overflows to exploiting the systemic complexity of cloud-native and microservices architectures. This newest list confirms the continued dominance of Broken Access Control (A01) and spotlights the critical surge of Security Misconfiguration (A02) to the number two spot, reflecting that infrastructure has become the primary attack surface. We examine why Software Supply Chain Failures (A03) became the new perimeter—despite limited presence in collected data—and discuss how integrating DevSecOps practices is the only way to meet modern development velocity.