In this final episode, Chiara De Biase and Jean Marco trace the journey of transluminal angioplasty from Charles Dotter in the US to Andreas Grüntzig in Europe. Grüntzig's vision was to apply balloon angioplasty to treat coronary artery stenosis, for which he defined clear goals and working axes. With determination, he collaborated with experts to develop a double-lumen balloon catheter and tested its safety and feasibility in animals and during bypass surgery. Despite scepticism, Grüntzig successfully performed the first percutaneous transluminal coronary angioplasty in September 1977, realising his dream.

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