What does it really take to launch a biotech company that lasts? In this episode, host Kim Kushner sits down with Dr. Marcia de Souza Lima, a physician-executive whose journey spans clinical care, global pharma, investment, and startup leadership. Together, they explore the earliest days of company formation—where every decision, from team design to product development, can shape the long-term path of the organization. 

The conversation begins with a familiar framework—the “Five P’s” of early biotech building: Product, People, Patents, Pennies, and Place. But Marcia challenges the idea that these alone are enough. She offers a fresh perspective on what leaders often overlook in the rush to build: the patient voice, the real-world context, and the flexibility to adapt as markets, teams, and therapies evolve. 

This Conversation Highlights: 

• Why scientific novelty isn’t enough—your product must be positioned to matter. 
• How to think about the patient perspective even before your first clinical milestone. 
• Ways to balance scientific rigor with entrepreneurial speed in a resource-constrained environment. 
• The talent trade-offs of hybrid vs. in-person teams—and how agility may be your biggest asset. 
• The role of mentorship, curiosity, and asking the right questions—especially when you're doing this for the first time. 

Rather than presenting a checklist, this episode invites biotech leaders to think more holistically: How do you build something both scientifically sound and human-centered? How do you grow fast—without missing the fundamentals? 

If you're leading (or planning to lead) in biotech, this is a conversation that helps you zoom out, refocus, and reconsider what should come first.