This episode reviews the current evidence for deep brain stimulation (DBS) as a treatment for clozapine-resistant schizophrenia. We examine the full text of the systematic review published in Neurosurgical Review in 2026, analyzing target-specific outcomes and stereotactic technical considerations from various studies. The discussion covers findings across different patient populations and clinical settings, highlighting key efficacy data and potential challenges. We explore the implications for neurosurgical practice and the future of neuromodulation in severe psychiatric disorders. This podcast is for informational purposes only and not a substitute for professional medical advice.