This episode delves into an innovative approach for treating severe, treatment-refractory obsessive-compulsive disorder (trOCD). We discuss the study design and individualized surgical targeting for deep brain stimulation (DBS) as outlined in "Stereo-encephalography-guided multi-lead deep brain stimulation for treatment-refractory obsessive compulsive disorder - Study design and individualized surgical targeting approach" published in the Journal of Affective Disorders in 2026, based on the abstract. The research utilizes stereo-encephalography (sEEG) to personalize multi-nodal target selection for DBS in a multi-site, randomized crossover clinical trial, addressing the network heterogeneity of trOCD. Listen in to understand the potential of this precise surgical strategy for a challenging patient population. This content is for informational purposes only and not a substitute for professional medical advice.