In this episode, we delve into the findings of a multicenter retrospective study published in Epilepsia Open in 2026, examining the full text of the research. The study investigates the efficacy and safety of stereo-EEG (sEEG)-guided responsive neurostimulation (RNS) in patients with neocortical epilepsy. Researchers analyzed data from a diverse patient population to assess seizure reduction and adverse events associated with this depth electrode-mediated neuromodulation technique. The key findings offer crucial insights for clinicians considering RNS as a treatment option for medically refractory epilepsy. This discussion is for informational purposes and does not constitute medical advice.