In this episode, we delve into the findings of a multicenter retrospective study published in Epilepsia Open in 2026, examining the efficacy and safety of stereo-EEG (sEEG)-guided responsive neurostimulation (RNS) for neocortical epilepsy. The study reviewed data from patients treated with depth electrode-mediated neuromodulation, offering valuable insights into seizure reduction and adverse events associated with this advanced therapeutic approach. Listen in as we discuss the practical applications and clinical implications of these results for managing refractory epilepsy. This podcast is for informational purposes and does not constitute medical advice. The content is based on the full text of the referenced study.