This episode delves into the efficacy of neurosurgical interventions for epilepsy in polymicrogyria, based on a systematic review published in Epilepsia Open in 2026. We examine the full text of this review, which synthesized existing research on surgical outcomes in patients with polymicrogyria and associated epilepsy. The discussion highlights the study's design, the populations and settings reviewed, and the key findings regarding seizure reduction and functional improvement. Clinicians will gain valuable insights into the current evidence supporting surgical approaches for this complex epilepsy syndrome. This content is for informational purposes and should not replace professional medical advice.