Fundic gland polyps (FGPs) develop sporadically (frequently after proton pump inhibitor therapy) or in the setting of a hereditary polyposis syndrome, such as familial adenomatous polyposis (FAP). In the later setting, FGPs often demonstrate low-grade dysplasia and are frequently associated with APC mutations. Sporadic FGPs with dysplasia also demonstrate frequent APC mutations.

Our guest, Dr. Won-Tak Choi, discusses the finding of his recent study on the topic where clinicopathologic features of 192 patients with FGPs were analyzed and DNA flow cytometry was performed.

Progression to advanced gastric neoplasia was rare in FGPs. None of the FAP-related and sporadic FGP biopsies, regardless of the presence or absence of dysplasia, demonstrated DNA content abnormality. This indicates that FGPs lack large-scale chromosomal changes that are characteristic of the typical adenoma-carcinoma sequence in gastrointestinal malignancies.