In this episode, we deliver a focused clinical review of acute cholecystitis, emphasizing the pathophysiology of gallbladder inflammation, classic presenting symptoms, and key physical exam findings. We walk through diagnostic strategies, including laboratory trends and imaging choices, and outline evidence-based management—from initial stabilization and antibiotics to indications for surgical intervention to help you confidently recognize and manage this common surgical condition.

References

1) Bushardt RL, Colomb-Lippa DM, Klinger AM, Reed H. The JAAPA QRS Review for PAs: Study Plan and Guide for PANCE and PANRE. 1st ed. LWW; 2021. ISBN: 9781975143817.

2) Gomes M, Queiroz de Figueiredo B, Menezes A, Júnior Á, Carvalho B, Roehrs D, Loureiro L, Nunes N, Borges C, Machado K. Acute cholecystitis: diagnosis, complications and therapy: an integrative literature review. Res Soc Dev. 2022;11:e322111537469. doi:10.33448/rsd-v11i15.37469.

3) Mencarini L, Vestito A, Zagari RM, Montagnani M. The diagnosis and treatment of acute cholecystitis: a comprehensive narrative review for a practical approach. J Clin Med. 2024;13(9):2695. doi:10.3390/jcm13092695. PMID:38731224

4) Radiopaedia Article Contributors (including Henry Knipe). Acute cholecystitis. Radiopaedia.org. Published online. Updated July 31, 2025. https://radiopaedia.org/articles/acute-cholecystitis?lang=gb. Accessed January 22, 2026.