In this episode, we review pyloric stenosis, a classic pediatric surgical condition every clinician should recognize. We cover the underlying pathophysiology of gastric outlet obstruction, hallmark clinical features such as projectile non-bilious vomiting, and key physical exam findings. The discussion highlights diagnostic imaging, electrolyte abnormalities, and evidence-based management, including preoperative stabilization and definitive surgical treatment.

References

1) Bushardt RL, Colomb-Lippa DM, Klinger AM, Reed H. The JAAPA QRS Review for PAs: Study Plan and Guide for PANCE and PANRE. 1st ed. LWW; 2021. ISBN: 9781975143817.

2) Vanderbilt University Medical Center Children's Quality & Safety. Pyloric Stenosis Clinical Practice Guideline. Vanderbilt University Medical Center; 2023. https://www.vumc.org/childrens-quality-safety/sites/default/files/public_files/Pyloric%20Stenosis%20CPG_06.20.23.pdf. Accessed January 22, 2026.

3) Garfield K, Sergent SR. Pyloric Stenosis. [Updated 2023 Jan 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK555931/