Source: Milan, Mascitelli, et al. (2025). “Low-Dose H₂O₂ Priming Improves Performance Under Simulated Marine Heatwave Conditions in a Coastal Bivalve.” Global Change Biology (Accepted). DOI: 10.1002/gch2.70123. PMC: PMC13266081Key terms:
Priming — controlled sublethal exposure that improves an organism’s later response to a larger stressor, via a form of physiological or molecular memoryMarine heatwave — a prolonged period of anomalously high ocean temperatures, increasingly frequent under climate changeRedox signaling — cellular communication using reactive oxygen species (like H₂O₂) as molecular signals, distinct from oxidative damageH₂O₂ (hydrogen peroxide) — here used as a low-dose redox stimulus at 50 micromolar, not as an environmental pollutantBurrowing behavior — used as a functional readout for clam physiological status; stressed animals burrow more slowlyTranscriptome — the complete set of RNA transcripts in a cell or tissue at a given moment; reflects gene activityHolobiont — the host animal plus all its associated microorganisms, considered as a functional unitManila clam (Ruditapes philippinarum) — one of the most farmed bivalves globally, particularly in coastal lagoons of southern Europe and Asia