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Two-thirds of your susceptibility to the CoVid virus is controlled by your genetic makeup while one-third is determined by environmental factors.   This the conclusion of a study by Columbia University biostatisticians following their study of 12, 764 patients with positive or negative CoVid PCR tests.

Their data demonstrated that, at the onset of the CoVid pandemic in 2020, environmental factors appeared to correlate with both the incidence and the severity of CoVid infections in about 57% of cases.  Heritability only explained about 43% of cases.

Such environmental factors include sick household members, community levels of disease, and measures taken to avoid disease spread including masking, social distancing, and quarantine.  By the end of 2021, heritability-genetic factors had become 1.5-times more important as environmental issues became less important with the advent of vaccine and infection-driven immunity.

Having reported these relationships, the researchers do point out that little is known to date about the actual genetics of CoVid infectibility.  One gene link association that is documented is that of CoVid susceptibility and ABO blood groups.  Those having type 0 blood groups are nearly 30% less likely to develop infection while those having type A blood groups were more than 30% more likely to develop infections.  

https://www.nature.com/articles/s41467-023-44250-7

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834371/

#CoVid #genetics #environmental #vaccination #masking #distancing