Link to bioRxiv paper:

http://biorxiv.org/cgi/content/short/2020.07.09.196436v1?rss=1

Authors: Junko Ogawa, Yoko Iwata, Nina U Tonnu, Chitra Gopinath, Ling Huang, Sachihiko Itoh, Ryoko Ando, Atsushi Miyawaki, Inder M Verma, Gerald M Pao

Abstract:

The optical refractive index of cellular components is generally not a property considered amenable to manipulation in microscopy as this is an intrinsic physical property of materials. Here we show that by targeting cephalopod reflectin protein nanoparticles one can manipulate the optical refractive index of mammalian cellular compartments. We further demonstrate that refractive index alteration based contrast agents can be utilized for dark field microscopy and quantitative phase contrast holotomography. Additionally we have molecularly cloned novel reflectins with improved and novel optical properties.

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