Welcome to Cardiology Today – Recorded November 24, 2025. This episode summarizes 4 key cardiology studies on topics like hypertrophic cardiomyopathy and proteomics. Key takeaway: Genetic Sodium Blockade for Arrhythmias.

Article Links:

Article 1: Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade. (Circulation)

Article 2: Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy. (Circulation. Heart failure)

Article 3: Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy. (Circulation. Heart failure)

Article 4: Effectiveness of high-dose influenza vaccine against hospitalisations in older adults (FLUNITY-HD): an individual-level pooled analysis. (Lancet (London, England))

Full episode page: https://podcast.explainheart.com/podcast/genetic-sodium-blockade-for-arrhythmias-11-24-25/

Journal: Circulation

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41277422

Summary: This study identified a specific Finnish-enriched SCN5A missense variant (T220I) that acts as a natural lifelong cardiac sodium channel blockade. Researchers found this genetic variant significantly impacts cardiac arrhythmias, associated mortality, and electrocardiogram phenotypes. The observational study encompassed over 1 million individuals across three large cohorts. These findings demonstrate a genetic proxy’s role in influencing cardiac electrical activity and associated clinical outcomes.

Journal: Circulation. Heart failure

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41277423

Summary: This research demonstrated that global proteoform alterations across multiple cellular compartments underlie obstructive hypertrophic cardiomyopathy. The study established that contributions beyond the sarcomere are significant to the heterogeneity of hypertrophic cardiomyopathy phenotypes. Top-down proteomics was identified as a powerful method for analyzing proteoforms, revealing their crucial role in disease mechanisms. These findings advanced the understanding of hypertrophic cardiomyopathy beyond traditional sarcomeric views.

Journal: Circulation. Heart failure

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41277423

Summary: This research demonstrated that global proteoform alterations across multiple cellular compartments underlie obstructive hypertrophic cardiomyopathy. The study established that contributions beyond the sarcomere are significant to the heterogeneity of hypertrophic cardiomyopathy phenotypes. Top-down proteomics was identified as a powerful method for analyzing proteoforms, revealing their crucial role in disease mechanisms. These findings advanced the understanding of hypertrophic cardiomyopathy beyond traditional sarcomeric views.

Journal: Lancet (London, England)

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41115437

Summary: This individual-level pooled analysis, FLUNITY-HD, integrated data from two large-scale trials conducted in Denmark and Spain, enhancing generalizability. The study determined the relative vaccine effectiveness of high-dose inactivated influenza vaccine compared to standard-dose inactivated influenza vaccine against severe clinical outcomes in older adults. This comprehensive assessment provided important comparative information on influenza vaccine efficacy for hospitalizations in this vulnerable population. The pooled analysis yielded a robust assessment of vaccine performance in older adults.

Today’s date is November 24, 2025. Welcome to Cardiology Today. Here are the latest research findings.

Article number one. Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade. This study identified a specific Finnish-enriched SCN5A missense variant (T220I) that acts as a natural lifelong cardiac sodium channel blockade. Researchers found this genetic variant significantly impacts cardiac arrhythmias, associated mortality, and electrocardiogram phenotypes. The observational study encompassed over 1 million individuals across three large cohorts. These findings demonstrate a genetic proxy’s role in influencing cardiac electrical activity and associated clinical outcomes.

Article number two. Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy. This research demonstrated that global proteoform alterations across multiple cellular compartments underlie obstructive hypertrophic cardiomyopathy. The study established that contributions beyond the sarcomere are significant to the heterogeneity of hypertrophic cardiomyopathy phenotypes. Top-down proteomics was identified as a powerful method for analyzing proteoforms, revealing their crucial role in disease mechanisms. These findings advanced the understanding of hypertrophic cardiomyopathy beyond traditional sarcomeric views.

Article number three. Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy. This research demonstrated that global proteoform alterations across multiple cellular compartments underlie obstructive hypertrophic cardiomyopathy. The study established that contributions beyond the sarcomere are significant to the heterogeneity of hypertrophic cardiomyopathy phenotypes. Top-down proteomics was identified as a powerful method for analyzing proteoforms, revealing their crucial role in disease mechanisms. These findings advanced the understanding of hypertrophic cardiomyopathy beyond traditional sarcomeric views.

Article number four. Effectiveness of high-dose influenza vaccine against hospitalisations in older adults (FLUNITY-HD): an individual-level pooled analysis. This individual-level pooled analysis, FLUNITY-HD, integrated data from two large-scale trials conducted in Denmark and Spain, enhancing generalizability. The study determined the relative vaccine effectiveness of high-dose inactivated influenza vaccine compared to standard-dose inactivated influenza vaccine against severe clinical outcomes in older adults. This comprehensive assessment provided important comparative information on influenza vaccine efficacy for hospitalizations in this vulnerable population. The pooled analysis yielded a robust assessment of vaccine performance in older adults.

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hypertrophic cardiomyopathy, proteomics, cardiac sodium channel, genetic variant, proteoforms, vaccine effectiveness, sarcomere, influenza vaccine, older adults, electrocardiogram, arrhythmias, cellular compartments, high-dose vaccine, hospitalizations, atrial fibrillation.

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