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In this podcast episode, nurse practitioner Gabriella McCarty and physician assistant Kim Orleck share expert insights on IBS with constipation (IBS-C)—one of the most common yet misunderstood gastrointestinal conditions. They explain how the diagnostic approach has shifted from a “diagnosis of exclusion” to a positive diagnostic strategy supported by ACG and AGA guidelines and the Rome criteria. Together, they highlight the importance of taking a thorough history, identifying red flags such as rectal bleeding, family history of colon cancer, unexplained weight loss, and anemia, while avoiding unnecessary and costly testing. Gabriella and Kim also explore how to communicate the brain–gut connection and concepts like visceral hypersensitivity to patients, helping them feel validated and understood rather than dismissed. By focusing on patient education, shared decision-making, and timely diagnosis, they show how providers can build confidence, reduce delays in care, and start treatment sooner for patients struggling with IBS-C. This conversation provides practical guidance for GI clinicians and reassurance for patients navigating IBS constipation. For more educational resources, visit GHAPP.org and explore the GHAPP ACE App.