Please visit answersincme.com/ADT860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in thoracic oncology discusses combination locoregional and systemic therapies in advanced non–small-cell lung cancer (NSCLC). Upon completion of this activity, participants should be better able to: Explain the rationale for combining locoregional therapies with immunotherapies to treat advanced NSCLC; Describe the clinical implications for combining novel locoregional therapies with systemic immunotherapy for advanced NSCLC; and Outline practical strategies to optimize treatment for combination therapy in advanced NSCLC.