The distinguished French painter Pierre Auguste Renoir was afflicted with arthritis that gradually crippled his hands.  Little by little his hands became gnarled and twisted, and it became increasingly painful to just hold a brush.  Anyone who has been strong and then has had pain begin to cripple him can relate to what Renoir went through, but Renoir's pain didn't go away with a few aspirin.  Eventually holding a brush became a painful challenge.  At last, the arthritis put him in a wheelchair and the easel had to be lowered for him to even reach it.