In this episode, Dr. Monica Diaz joins to discuss key global developments in multiple sclerosis presented at the 2025 ECTRIMS Congress. The conversation explores updated diagnostic criteria for MS and NMOSD, advances in disease-modifying therapies, emerging safety data in pregnancy and breastfeeding, and the growing evidence on how social determinants of health shape MS outcomes worldwide. Together, the hosts highlight both the scientific progress and the equity challenges that must be addressed to improve brain health for people living with MS globally.