In this episode, we examine whether GLP-1 medications like semaglutide and tirzepatide can affect mood and mental health. We explore the science behind GLP-1 receptors in the brain, review clinical trial and real-world evidence, discuss three mechanisms through which these medications could influence mood including direct CNS effects, psychological adjustment to appetite changes, and blood sugar fluctuations, and provide practical guidance for patients and prescribers. Follow us on social media for updates and more content.