The Stay Juicy Podcast

GLP-1s + Estrogen: A New Era in Menopause Metabolism


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Hey family! October is Menopause Awareness Month — but let’s be real, around here every month is menopause awareness month.
In this episode, we’re talking about one of the biggest conversations in midlife medicine right now: GLP-1s, GIPs, and how estrogen plays a massive role in metabolism and weight. If you’ve been doing all the right things and that “meno belly” still won’t budge, this episode is for you. We’re breaking down the science, the hype, and the truth about what’s happening in your body — and how you can support it with grace, knowledge, and power.


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Timestamped Overview

  • 00:00–01:30 — Menopause Awareness Month and the reality of midlife weight changes

  • 01:30–04:30 — Why estrogen plays a key role in fat metabolism

  • 04:30–09:00 — Understanding GLP-1s and GIPs: what they are and how they work

  • 09:00–12:00 — The Endocrine Society data on combining GLP-1 therapy with estrogen

  • 12:00–16:00 — The rise of new medications: retatrutide, trulicity, rebelsus, and others

  • 16:00–20:00 — How estrogen regulates metabolism and insulin sensitivity

  • 20:00–27:00 — What happens when you stop taking GLP-1s and how to taper wisely

  • 27:00–31:00 — Why yo-yo dieting can be more dangerous in midlife

  • 31:00–35:00 — Long-term strategies for maintaining muscle and metabolic health

  • 35:00–39:00 — The importance of individualized care and Tula’s holistic approach

  • 39:00–41:00 — Closing reflections: You’re not losing yourself — you’re finding your strongest self

...more
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The Stay Juicy PodcastBy Dr. Arianna