What's the difference between a Genetically Modified plant and a Hybrid? First, genetic mutations have been going on forever. Think a male and female mate and have a baby... that's a genetic modification, naturally. Hybridizers have been doing this for a long time breeding various plants by hand. Genetically modified plants are created in a lab. There's a lot to this discussion, is it wrong? Is it a smart way to feed all the people we have on Earth? I have more on my website too. Check it out GardenBite.