Got APOE4? Here’s the exact prevention strategy I would use to protect my own brain if I carried this gene.

In this video, I walk through the major modifiable dementia risk factors identified by the Lancet Commission — and how I would actually approach them in real life as a vascular surgeon specializing in cardiometabolic prevention.

We cover:
* ApoB, vascular disease, and why “brain health” starts in the arteries
* What you can do NOW without any clinical support
* Blood pressure, insulin resistance, exercise, sleep, and inflammation
* Hearing loss, social isolation, alcohol, smoking, and other overlooked dementia risks
* Which interventions matter most
* How I prioritize prevention clinically
* What people with APOE4 often misunderstand about risk

⏰ Chapters:
0:00 Almost Half of Dementia Cases May Be Preventable
0:24 APOE4 Is Not Fate
0:53 Why a Vascular Surgeon Cares About Dementia
2:05 Meet “Carol”: APOE4, Family History, and Fear
3:11 The Lancet Commission’s 14 Modifiable Risk Factors
5:29 Why APOE4 Carriers Still Have Real Hope
6:48 What You Can Start Doing Without a Prescription
7:08 Exercise: The Biggest Lever for Brain Health
8:49 The 4 Exercise Buckets I Recommend
11:56 How to Eat for an APOE4 Brain
16:49 Why I’d Keep Alcohol Near Zero
19:16 Loneliness, Social Connection, and Dementia Risk
21:29 When to Bring Your Doctor Into the Plan
22:11 Make Your Lipids Boring
24:47 Obicetrapib, pTau217, and New Alzheimer’s Biomarkers
29:58 Blood Pressure and APOE4 Risk
32:06 Sleep, Sleep Apnea, and the Brain’s Cleaning System
33:54 Insulin Resistance Is a Brain Problem
36:54 Hearing Loss and Cognitive Decline
38:39 The Shingles Vaccine Dementia Data
41:23 Bonus: Hormones, Homocysteine, and Dental Health
45:37 Why Supplements Are Part 3

APOE4 is NOT destiny. But it is a signal to get serious earlier, and there's so much you can do TODAY to head in the right direction.

Missed Part 1? Check it out here: 
https://youtu.be/y8vkJE_Zy7A

Sign up for more information on my own practice here: https://corsighthealth.com/

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🧬 About Dr. Lily Johnston
  
Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.

Disclaimer: This video is for educational purposes only and does not constitute medical advice or establish a doctor-patient relationship.