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Grail's Josh Ofman on the Revolution of Cancer Screening
Out of all the dozens of types of cancer that occur in humans, we habitually screen for only five: breast, cervical, colon, prostate, and lung. But what if there were a single test that could detect 50 types of cancer, based on a simple blood draw? That's exactly what's possible today, thanks to the Galleri test, introduced by Illumina spinoff Grail in 2021. The $949 test, which won breakthrough designation from the FDA in 2019, uses machine learning to assess the patterns of methyl groups—molecules that attach to chromosomes and control gene activity—in free-floating DNA shed by tumors.
This week Harry interviews Grail's president, Dr. Josh Ofman. He says that the company is working to bring down the price of the test, and that if multi-cancer early detection tests like Galleri are eventually approved for population-level screening, it could help avert 100,000 deaths per year.
For a full transcript of this episode, please visit our episode page at http://www.glorikian.com/podcast
Please rate and review The Harry Glorikian Show on Apple Podcasts! Here's how to do that from an iPhone, iPad, or iPod touch:
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By Harry GlorikianOut of all the dozens of types of cancer that occur in humans, we habitually screen for only five: breast, cervical, colon, prostate, and lung. But what if there were a single test that could detect 50 types of cancer, based on a simple blood draw? That's exactly what's possible today, thanks to the Galleri test, introduced by Illumina spinoff Grail in 2021. The $949 test, which won breakthrough designation from the FDA in 2019, uses machine learning to assess the patterns of methyl groups—molecules that attach to chromosomes and control gene activity—in free-floating DNA shed by tumors.
This week Harry interviews Grail's president, Dr. Josh Ofman. He says that the company is working to bring down the price of the test, and that if multi-cancer early detection tests like Galleri are eventually approved for population-level screening, it could help avert 100,000 deaths per year.
For a full transcript of this episode, please visit our episode page at http://www.glorikian.com/podcast
Please rate and review The Harry Glorikian Show on Apple Podcasts! Here's how to do that from an iPhone, iPad, or iPod touch:
1. Open the Podcasts app on your iPhone, iPad, or Mac.
2. Navigate to The Harry Glorikian Show podcast. You can find it by searching for it or selecting it from your library. Just note that you'll have to go to the series page which shows all the episodes, not just the page for a single episode.
3. Scroll down to find the subhead titled "Ratings & Reviews."
4. Under one of the highlighted reviews, select "Write a Review."
5. Next, select a star rating at the top — you have the option of choosing between one and five stars.
6. Using the text box at the top, write a title for your review. Then, in the lower text box, write your review. Your review can be up to 300 words long.
7. Once you've finished, select "Send" or "Save" in the top-right corner.
8. If you've never left a podcast review before, enter a nickname. Your nickname will be displayed next to any reviews you leave from here on out.
9. After selecting a nickname, tap OK. Your review may not be immediately visible.
That's it! Thanks so much.