James Watson and Francis Crick collected and interpreted key evidence to determine that DNA molecules take the shape of a twisted ladder—a double helix. The film presents the challenges, false starts, and eventual success of their bold chase, culminating in the classic 1953 publication in Nature on the structure of DNA. Watson relates what those early days in the Cavendish Laboratory were like, including his friendship with Crick and their shared ambition and passion. Rarely seen archival footage is combined with interviews with some of today’s leading scientists to bring this landmark discovery and all of its implications to life.