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This Week In Startups is made possible by:
PAYPAL OPEN
Today’s show:
The price of tokens keeps tumbling down, and it’s changing who controls AI.
Grok 4.5 and GLM-5.2 landed within two weeks of one another, offering powerful alternatives at a fraction of frontier prices. But are SpaceXAI’s latest offering and open weight models truly ready to replace Opus, GPT-5.5, and Fable? Are enterprises finally ready to stop renting and start owning their intelligence?
On TWiAI Episode 22, Jason and Lon welcome three top founders — Sara Hooker (Adaption Labs), Manu Sharma (Labelbox), and Spiros Xanthos (Resolve AI) — to break down the global AI price war, and what it means for the frontier labs and customers alike. Plus Denis Hassabis’ call for an AI Standards Body, Uber and Waymo duke it out over DC robotaxis, and is SpaceXAI really going to put data centers in orbit any time soon?
Guests:
Sara Hooker on X: https://x.com/sarahookr
Adaption Labs: https://adaptionlabs.ai/
Manu Sharma on X: https://x.com/manuaero
Labelbox: https://labelbox.com/
Spiros Xanthos on X: https://x.com/spirosx
Resolve AI: https://resolve.ai/
Relevant Links
Introducing Grok 4.5**:** https://x.ai/news/grok-4-5
GLM from Z.ai: https://z.ai
Artificial Analysis Intelligence Index: https://artificialanalysis.ai/
Demis Hassabis: “A Framework for Frontier AI and the Dawning of a New Age”: https://x.com/demishassabis/status/2076957440109625718
Cerebras: https://www.cerebras.ai/
Austin Allred post cited by Jason: https://x.com/Austen/status/2076745226387902925
TechCrunch coverage of DC autonomous driving bill: https://techcrunch.com/2026/07/13/ubers-robotaxi-lobbying-effort-has-put-it-on-a-collision-course-with-waymo/
DoorDash: Meet Dot: https://about.doordash.com/en-us/dot
TechCrunch coverage of orbital data center debate: https://techcrunch.com/2026/07/13/sam-altmans-space-data-center-trash-talk-is-what-most-experts-already-believe
Falcon 9 booster’s record 36th flight: https://spaceflightnow.com/2026/07/09/live-coverage-spacex-to-launch-falcon-9-rocket-on-record-breaking-36th-flight/
Timestamps:0:00 A new generation of lower-cost models
4:10 Enterprises want their own intelligence stack
6:10 Frontier vs. open source: where does the value go?
10:03 Is enterprises destined to go small?
30:04 Self-improvement as the real fix
31:52 Should the AI industry regulate itself?
47:14 Uber vs. Waymo in DC
1:03:53 Can AI data centers in space really work?
1:14:47 You get a plug! Everyone gets a plug!
Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com
Check out the TWIST500: https://www.twist500.com
Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp
Follow Lon:
X: https://x.com/lons
Follow Alex:
X: https://x.com/alex
LinkedIn: https://www.linkedin.com/in/alexwilhelm
Follow Jason:
X: https://twitter.com/Jason
LinkedIn: https://www.linkedin.com/in/jasoncalacanis
Check out all our partner offers: https://partners.launch.co/
Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland
Check out Jason’s suite of newsletters: https://substack.com/@calacanis
Follow TWiST:
Twitter: https://twitter.com/TWiStartups
YouTube: https://www.youtube.com/thisweekin
Instagram: https://www.instagram.com/thisweekinstartups
TikTok: https://www.tiktok.com/@thisweekinstartups
Substack: https://twistartups.substack.com
By Jason CalacanisThis Week In Startups is made possible by:
PAYPAL OPEN
Today’s show:
The price of tokens keeps tumbling down, and it’s changing who controls AI.
Grok 4.5 and GLM-5.2 landed within two weeks of one another, offering powerful alternatives at a fraction of frontier prices. But are SpaceXAI’s latest offering and open weight models truly ready to replace Opus, GPT-5.5, and Fable? Are enterprises finally ready to stop renting and start owning their intelligence?
On TWiAI Episode 22, Jason and Lon welcome three top founders — Sara Hooker (Adaption Labs), Manu Sharma (Labelbox), and Spiros Xanthos (Resolve AI) — to break down the global AI price war, and what it means for the frontier labs and customers alike. Plus Denis Hassabis’ call for an AI Standards Body, Uber and Waymo duke it out over DC robotaxis, and is SpaceXAI really going to put data centers in orbit any time soon?
Guests:
Sara Hooker on X: https://x.com/sarahookr
Adaption Labs: https://adaptionlabs.ai/
Manu Sharma on X: https://x.com/manuaero
Labelbox: https://labelbox.com/
Spiros Xanthos on X: https://x.com/spirosx
Resolve AI: https://resolve.ai/
Relevant Links
Introducing Grok 4.5**:** https://x.ai/news/grok-4-5
GLM from Z.ai: https://z.ai
Artificial Analysis Intelligence Index: https://artificialanalysis.ai/
Demis Hassabis: “A Framework for Frontier AI and the Dawning of a New Age”: https://x.com/demishassabis/status/2076957440109625718
Cerebras: https://www.cerebras.ai/
Austin Allred post cited by Jason: https://x.com/Austen/status/2076745226387902925
TechCrunch coverage of DC autonomous driving bill: https://techcrunch.com/2026/07/13/ubers-robotaxi-lobbying-effort-has-put-it-on-a-collision-course-with-waymo/
DoorDash: Meet Dot: https://about.doordash.com/en-us/dot
TechCrunch coverage of orbital data center debate: https://techcrunch.com/2026/07/13/sam-altmans-space-data-center-trash-talk-is-what-most-experts-already-believe
Falcon 9 booster’s record 36th flight: https://spaceflightnow.com/2026/07/09/live-coverage-spacex-to-launch-falcon-9-rocket-on-record-breaking-36th-flight/
Timestamps:0:00 A new generation of lower-cost models
4:10 Enterprises want their own intelligence stack
6:10 Frontier vs. open source: where does the value go?
10:03 Is enterprises destined to go small?
30:04 Self-improvement as the real fix
31:52 Should the AI industry regulate itself?
47:14 Uber vs. Waymo in DC
1:03:53 Can AI data centers in space really work?
1:14:47 You get a plug! Everyone gets a plug!
Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com
Check out the TWIST500: https://www.twist500.com
Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp
Follow Lon:
X: https://x.com/lons
Follow Alex:
X: https://x.com/alex
LinkedIn: https://www.linkedin.com/in/alexwilhelm
Follow Jason:
X: https://twitter.com/Jason
LinkedIn: https://www.linkedin.com/in/jasoncalacanis
Check out all our partner offers: https://partners.launch.co/
Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland
Check out Jason’s suite of newsletters: https://substack.com/@calacanis
Follow TWiST:
Twitter: https://twitter.com/TWiStartups
YouTube: https://www.youtube.com/thisweekin
Instagram: https://www.instagram.com/thisweekinstartups
TikTok: https://www.tiktok.com/@thisweekinstartups
Substack: https://twistartups.substack.com