The full story behind this week's trailer: Longitudinal Changes in Body Composition, Adaptive Thermogenesis and Muscle Strength in Patients with Obesity Treated with Semaglutide

Chapters
00:03 — Cold open
00:46 — What is semaglutide
01:36 — Why body composition matters
02:35 — Study design
04:07 — Weight loss results
04:47 — Body composition
05:26 — The SMI-SDS metric
06:51 — Handgrip strength
07:31 — A word from our sponsor
08:14 — Adaptive thermogenesis
10:14 — Caveats
12:11 — Bottom line
13:05 — Sign-off

Links (some are reklamelinks and can earn the show a commission)

• Paper: Longitudinal Changes in Body Composition, Adaptive Thermogenesis and Muscle Strength in Patients with Obesity Treated with Semaglutide (Obesity Facts)
• Sponsor: Epilators on Amazon

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The full story behind this week's trailer: Responsiveness of epigenetic aging biomarkers to longevity interventions in humans

Chapters
00:03 — Cold open
00:44 — What is an epigenetic clock
02:13 — Second and third generation clocks
03:55 — The problem
04:30 — TranslAGE
05:35 — Key findings
06:48 — Why some clocks respond
08:27 — A word from our sponsor
09:08 — Which interventions work
10:15 — Study design matters
11:17 — Caveats
13:44 — What this means
14:59 — Bottom line
15:35 — Sign-off

Links (some are reklamelinks and can earn the show a commission)

• Paper: Responsiveness of epigenetic aging biomarkers to longevity interventions in humans (Nature Medicine)
• Sponsor: Hair-loss shampoo on Amazon

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# Hastrup Review of Science — Week 35, 2026 ## Papers covered ### 1. Responsiveness of epigenetic aging biomarkers to longevity interventions in humans **Authors:** Raghav Sehgal, Daniel Borrus, Jenel F. Armstrong, John Gonzalez, Jessica Kasamoto, Yaroslav Markov, Ahana Priyanka, Ryan Smith **Journal:** Nature Medicine (2026-08-21) **DOI:** 10.1038/s41591-026-04562-9 **Link:** https://doi.org/ Sponsor links: see referrals (reklamelinks).

Chapters
00:03 — Sponsor: RefurbMiner
00:23 — Cold open
01:15 — Epigenetic clocks on trial
02:43 — Semaglutide and body composition
04:12 — Ad break
04:43 — Lifelong sport and sarcopenia
05:58 — Dark matter from the Milky Way
07:22 — Lab earthquakes
08:42 — Sign-off

Links (some are reklamelinks and can earn the show a commission)

• RefurbMiner — Free 14-day trial
• Caffeine Shampoo for Men (This week's sponsor)
• Sehgal et al. — Epigenetic aging biomarkers (Nature Medicine)
• Filippi-Arriaga et al. — Semaglutide body composition (Obesity Facts)
• Olszowiec et al. — Lifelong sport and sarcopenia (Quality in Sport)
• Mukhopadhyay & Krnjaic — IceCube dark matter limits (arXiv)
• Shafir et al. — Lab earthquakes and slip pulses (arXiv)

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The full story behind this week's trailer: Mg2RhH6 superconductivity at 30 GPa via two-step precursor synthesis

Chapters
00:03 — Cold open
00:44 — Why hydrogen
01:52 — The pressure wall
03:00 — Why pressure matters
04:07 — The two-step synthesis
05:34 — The structural transition
06:14 — Why rhodium
07:19 — The evidence
08:33 — A word from our sponsor
09:13 — The broader strategy
10:41 — Context and comparison
11:37 — Caveats
13:43 — What comes next
14:47 — Sign-off

Links (some are reklamelinks and can earn the show a commission)

• Paper: Mg2RhH6 superconductivity at 30 GPa via two-step precursor synthesis (arXiv)
• Sponsor: Potency supplements on Amazon

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The full story behind this week's trailer: Machine-designed hard carbon structures for sodium-ion batteries

Chapters
00:03 — Cold open
00:46 — Why sodium
01:44 — The graphite problem
02:37 — What hard carbons look like
03:39 — The modelling problem
04:30 — Machine-learned potentials
05:16 — The RAFFLE framework
06:08 — Validation
06:59 — Sodium intercalation
07:59 — A word from our sponsor
08:40 — The surrogate model
09:44 — High-capacity candidates
10:36 — Design principles
11:26 — Caveats
13:26 — What comes next
15:04 — Sign-off

Links (some are reklamelinks and can earn the show a commission)

• Paper: Atomistic Structure Generation and Neural-Network Screening of Hard Carbons (arXiv)
• Sponsor: Ice cube trays on Amazon

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The full story behind this week's trailer: Axion search in the diffuse supernova neutrino background at Super-Kamiokande

Chapters
00:03 — Cold open
00:39 — Core-collapse supernovae
01:36 — SN 1987A
02:08 — The diffuse supernova neutrino background
03:01 — The Super-K detection
04:47 — The strong CP problem and axions
06:43 — Axions in supernovae
08:16 — A word from our sponsor
08:53 — The method
10:17 — The result
11:00 — Why the DSNB matters
12:32 — Caveats
14:04 — What comes next
15:22 — Sign-off

Links (some are reklamelinks and can earn the show a commission)

• Paper: An axion constraint from the diffuse supernova neutrino background indicated by Super-Kamiokande (arXiv)
• Reference: Search for Diffuse Supernova Neutrino Background with Super-Kamiokande Gadolinium Dataset (ApJ)
• Sponsor: Clothes pegs on Amazon

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The full story behind this week's trailer: TMEM106B structural haplotypes and neurodegeneration risk

Chapters
00:03 — Cold open
00:37 — What is TMEM106B
01:49 — The original risk variant
02:50 — The 2022 surprise
04:20 — Long-read sequencing
05:31 — The four haplotypes
07:45 — The retrotransposon
09:08 — A word from our sponsor
09:42 — The mechanism
11:45 — Lysosomal rupture
13:29 — Causal evidence
13:57 — Caveats
15:40 — What comes next
17:24 — Sign-off

Links (some are reklamelinks and can earn the show a commission)

• Paper: Fine-mapping of the TMEM106B locus (medRxiv preprint)
• Companion: Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation (bioRxiv)
• Sponsor: Nose-hair trimmers on Amazon

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The full story behind this week's trailer: RNA Polymerase II developmental overshoot as a driver of aging

Chapters
00:03 — Cold open
00:48 — What is Pol II
01:29 — The overshoot
03:10 — The decline
04:59 — A word from our sponsor
05:32 — The experiments
07:07 — Conservation
07:50 — Theoretical context
09:00 — Implications and limits
09:55 — Caveats
11:22 — What comes next
12:38 — Sign-off

Links (some are reklamelinks and can earn the show a commission)

• Paper: RNA Polymerase II developmental overshoot as a driver of aging (bioRxiv)
• Sponsor: Beard oil on Amazon

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# Hastrup Review of Science — 2026-W34b (Special Episode) ## 1. Imaging the Vacuum Fluctuations of a Quantum Field **Authors:** Zhang, Wang, Jiang, Jenkins, Wong, Eigen, Carlse, Hadzibabic **Venue:** arXiv preprint (2026-08-20, cond-mat.quant-gas) **Link:** https://arxiv.org/abs/2608.20311 Firs

Chapters
00:03 — Sponsor: RefurbMiner
00:24 — Cold open
01:02 — Imaging the vacuum
02:38 — GLP one drugs and muscle
04:14 — A word from our sponsor
04:52 — Black holes on a chip
06:28 — Heat on demand
07:57 — Competing supersolids
09:25 — Sign-off

Links (some are reklamelinks and can earn the show a commission)

• Sponsor: RefurbMiner — free 14-day trial
• Paper: Imaging the vacuum fluctuations (arXiv)
• Paper: GLP-1 receptor agonists and skeletal muscle (Quality in Sport)
• Paper: Black hole thermality on a quantum processor (arXiv)
• Paper: Thermal power amplification via Q-switching (arXiv)
• Paper: Competing supersolid orders in a dipolar gas (arXiv)
• Sponsor: Caffeine shampoo on Amazon

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Five papers, honestly explained: a developmental cause of aging, TMEM106B haplotypes, a supernova axion hunt, machine-designed sodium-ion carbons, and a low-pressure superconducting hydride. One suspicious sponsor.

Chapters
00:03 — Sponsor: RefurbMiner ERP
00:24 — Cold open
01:00 — Aging: the Pol II overshoot
02:35 — TMEM106B: four haplotypes
04:02 — Ghost supernovae and axions
05:33 — A word from our sponsor
06:11 — Sodium-ion by the billion
08:10 — A superconducting hydride
10:07 — Sign-off

Links (some are reklamelinks and can earn the show a commission)

• Paper: Pol II developmental overshoot and aging (bioRxiv)
• Paper: TMEM106B haplotypes (medRxiv)
• Paper: Supernova axion search (arXiv)
• Paper: ML-designed sodium-ion carbons (arXiv)
• Paper: Mg2RhH6 superconductivity (arXiv)
• Sponsor: RefurbMiner — free 14-day trial
• Sponsor: Tampons on Amazon

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