Welcome to Cardiology Today – Recorded November 26, 2025. This episode summarizes 5 key cardiology studies on topics like cardiotoxicity and bicuspid aortic stenosis. Key takeaway: Heart Failure Drug Access Disparities Identified..

Article Links:

Article 1: Incident cardiovascular events in women with left-sided versus right-sided breast cancer: a propensity score-matched study. (Heart (British Cardiac Society))

Article 2: Surveillance of left ventricular function among cancer survivors. (Heart (British Cardiac Society))

Article 3: Amphilimus-eluting versus zotarolimus-eluting stents in patients with diabetes mellitus and coronary artery disease: extended follow-up of the SUGAR randomised controlled trial. (Heart (British Cardiac Society))

Article 4: Outcomes of transcatheter aortic valve replacement in bicuspid versus tricuspid aortic stenosis with severe calcification. (Heart (British Cardiac Society))

Article 5: Disparities in prescriptions among Danish heart failure patients: a national longitudinal cohort study. (Heart (British Cardiac Society))

Full episode page: https://podcast.explainheart.com/podcast/heart-failure-drug-access-disparities-identified-11-26-25/

Journal: Heart (British Cardiac Society)

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40829861

Summary: Cardiotoxic effects of breast cancer therapies, including drugs and radiotherapy, are known to increase cardiovascular morbidity, particularly atrial fibrillation. This study precisely evaluated laterality-specific cardiovascular risks in women with left-sided versus right-sided breast cancer. Utilizing global healthcare data from the TriNetX network, the research clarified the specific impact of breast cancer laterality on incident cardiovascular events.

Journal: Heart (British Cardiac Society)

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40763997

Summary: Cancer survivors demonstrate an increased risk of heart failure, which is balanced by the risk of death from other causes, influencing optimal cardiac surveillance timing. This cross-sectional study investigated the association between cancer history and cardiac function across various follow-up periods. The research provided crucial data for determining effective guideline-recommended surveillance strategies for left ventricular function in this patient population.

Journal: Heart (British Cardiac Society)

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40562528

Summary: Patients with diabetes mellitus receiving percutaneous coronary intervention experience an elevated risk of late adverse events. The Second-generation Drug-eluting Stents in Diabetes (SUGAR) randomized controlled trial compared amphilimus-eluting stents and onyx-zotarolimus-eluting stents in this high-risk population. The study reported the co-primary endpoint of target lesion failure at two years and extended follow-up at three years. This research provided critical comparative data on stent performance and long-term outcomes for diabetic patients.

Journal: Heart (British Cardiac Society)

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40348412

Summary: The comparative outcomes of transcatheter aortic valve replacement in bicuspid versus tricuspid aortic stenosis with severe calcification remained unclear. This study rigorously compared the safety and efficacy of transcatheter aortic valve replacement in these patient groups. Researchers analyzed 870 propensity score matched pairs of patients with severe calcification exceeding 470 cubic millimeters. The research clarified specific outcomes to guide optimal treatment strategies for aortic stenosis.

Journal: Heart (British Cardiac Society)

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40348409

Summary: Angiotensin receptor-neprilysin inhibitors and sodium-glucose co-transporter two inhibitors hold a Class one indication for acute and chronic heart failure due to benefits in symptom management, rehospitalization, and mortality. This national longitudinal cohort study investigated demographic, geographic, and socioeconomic disparities in the prescription of these essential medications for heart failure patients. The research identified patterns of unequal access to guideline-recommended heart failure therapies among Danish patients, highlighting areas for intervention.

Today’s date is November 26, 2025. Welcome to Cardiology Today. Here are the latest research findings.

Article number one. Incident cardiovascular events in women with left-sided versus right-sided breast cancer: a propensity score-matched study. Cardiotoxic effects of breast cancer therapies, including drugs and radiotherapy, are known to increase cardiovascular morbidity, particularly atrial fibrillation. This study precisely evaluated laterality-specific cardiovascular risks in women with left-sided versus right-sided breast cancer. Utilizing global healthcare data from the TriNetX network, the research clarified the specific impact of breast cancer laterality on incident cardiovascular events.

Article number two. Surveillance of left ventricular function among cancer survivors. Cancer survivors demonstrate an increased risk of heart failure, which is balanced by the risk of death from other causes, influencing optimal cardiac surveillance timing. This cross-sectional study investigated the association between cancer history and cardiac function across various follow-up periods. The research provided crucial data for determining effective guideline-recommended surveillance strategies for left ventricular function in this patient population.

Article number three. Amphilimus-eluting versus zotarolimus-eluting stents in patients with diabetes mellitus and coronary artery disease: extended follow-up of the SUGAR randomised controlled trial. Patients with diabetes mellitus receiving percutaneous coronary intervention experience an elevated risk of late adverse events. The Second-generation Drug-eluting Stents in Diabetes (SUGAR) randomized controlled trial compared amphilimus-eluting stents and onyx-zotarolimus-eluting stents in this high-risk population. The study reported the co-primary endpoint of target lesion failure at two years and extended follow-up at three years. This research provided critical comparative data on stent performance and long-term outcomes for diabetic patients.

Article number four. Outcomes of transcatheter aortic valve replacement in bicuspid versus tricuspid aortic stenosis with severe calcification. The comparative outcomes of transcatheter aortic valve replacement in bicuspid versus tricuspid aortic stenosis with severe calcification remained unclear. This study rigorously compared the safety and efficacy of transcatheter aortic valve replacement in these patient groups. Researchers analyzed 870 propensity score matched pairs of patients with severe calcification exceeding 470 cubic millimeters. The research clarified specific outcomes to guide optimal treatment strategies for aortic stenosis.

Article number five. Disparities in prescriptions among Danish heart failure patients: a national longitudinal cohort study. Angiotensin receptor-neprilysin inhibitors and sodium-glucose co-transporter two inhibitors hold a Class one indication for acute and chronic heart failure due to benefits in symptom management, rehospitalization, and mortality. This national longitudinal cohort study investigated demographic, geographic, and socioeconomic disparities in the prescription of these essential medications for heart failure patients. The research identified patterns of unequal access to guideline-recommended heart failure therapies among Danish patients, highlighting areas for intervention.

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cardiotoxicity, bicuspid aortic stenosis, tricuspid aortic stenosis, heart failure, laterality, zotarolimus-eluting stents, amphilimus-eluting stents, cardiovascular events, diabetes mellitus, valve replacement, guideline adherence, transcatheter aortic valve replacement, percutaneous coronary intervention, angiotensin receptor-neprilysin inhibitors, prescription disparities, breast cancer, left ventricular dysfunction, sodium-glucose co-transporter two inhibitors, cardiac surveillance, drug-eluting stents, cancer survivors, severe calcification, atrial fibrillation.

Concise summaries of cardiovascular research for professionals.

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