PodBites

Hematology | Bone Marrow Failure Syndromes

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🍐 In this episode of PodBites, Jana Atef and Lema Sibai break down one of hematology’s most intimidating topics — Bone Marrow Failure Syndromes — and turn it into a clear, structured, and genuinely enjoyable conversation.

🎙️ Tune in to learn about:

  • What bone marrow failure actually means — and why pancytopenia is the key clue.
  • Aplastic anemia: pathophysiology, severity grading, causes, and biopsy findings.
  • Drugs, toxins, viruses, radiation & autoimmunity — the major culprits behind acquired marrow failure.
  • The full diagnostic workup: reticulocytes, smear clues, marrow biopsy, viral studies, and genetic testing.
  • Fanconi anemia: DNA repair defect, congenital anomalies, chromosomal breakage testing.
  • TAR syndrome and the classic “radii absent, thumbs present” exam trick
  • How to approach pancytopenia using a clean flowchart: production vs. destruction vs. infiltration.
  • Treatment options — from immunosuppression (ATG + cyclosporine) to stem-cell transplant.

    • 🌟 A comprehensive, high-yield, and deeply intuitive walkthrough of bone marrow failure syndromes — perfect for exam prep, clinical reasoning, or anyone tired of memorizing hematology without understanding it.

     

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    PodBitesBy palbites2023