PodBites

Hematology | Hemoglobinopathies

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🍐 In this high-yield episode of PodBites, Jude Jamjoom and Nour Alfarra take you on a clear, case-based journey through the entire world of hemoglobinopathies — from the structure of hemoglobin, all the way to the molecular mutations behind thalassemias and sickle cell disorders.

🎙️ Tune in to learn about:

  • How normal hemoglobin is built — globin chains, gene locations, and the fetal-to-adult switch.
  • When to suspect a hemoglobinopathy based on clinical red flags
  • The full lab toolkit beyond electrophoresis: O₂ curves, stability tests, stains, & molecular diagnostics.
  • How to decode peripheral smear findings (target cells, sickled cells, Heinz bodies, basophilic stippling).
  • β-Thalassemia Minor, Intermedia & Major — explained through real patient cases.
  • α-Thalassemia: including HbH Disease with its classic “golf-ball” inclusions.
  • Distinguishing Thalassemia from Iron Deficiency Anemia using Mentzer Index & RBC patterns.
  • Hb D-Punjab: benign alone, significant when co-inherited.
  • Sickle Cell Trait vs. Sickle Cell Disease — clinical features, crises, and management.
  • High-yield recap questions woven throughout the episode.

    • 🌟 A thorough, engaging, and clinically grounded walkthrough of hemoglobinopathies — perfect for learners who want the molecular, morphological, and real-life reasoning all in one place.

     

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    PodBitesBy palbites2023