In this episode of the Research Digest Podcast, we discussedthe article titled “Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation”, published in ACS Nano (2023). We spoke with the lead author, Dr. Deena Al Mahbuba, about the background of the research work, its major findings, and future perspectives.

THIS EPISODE on YOUTUBE

https://youtu.be/rtVNZWDLmtU

ARTICLE LINK

https://pubs.acs.org/doi/full/10.1021/acsnano.2c10072

TIMESTAMPS

00:00 – Introduction

01:20 – Career journey of the author

04:45 – Introducing the author

05:30 – Starting the project and the knowledge gap

11:30 – Heparan sulfate proteoglycans and their importance

15:40 – Expansion microscopy

22:00 – Major findings and observations

32:00 – Role of heparan sulfate in the fate decision of hematopoietic stem cells

38:20 – Challenges of the project

43:40 – Message to the young scientists