Dr. Lauren Rybolt, Assistant Professor of Medicine at the USF Morsani College of Medicine, presents a talk on how to to tailor strategies for Pre-exposure prophylaxis, or “PREP,” to the individual patient. Dr. Rybolt begins by discussing USPSTF recommendations. She then moves on to compare and contrast the currently available options for PREP therapy, including TDF/FTC versus TAF/FTC, Cabotegravir, and Lenacapavir. Dr. Rybolt then discusses laboratory monitoring while on the drugs and modifications of PREP therapy in a patient who also has chronic hepatitis B. She closes with her final points regarding the individualization of PREP treatment and the need to continuously assess the patient’s ongoing risk factors.